Prior work characterized common cancer-associated and other missense mutations in BRG1, which localize to the surface of the RecA-like lobes, the ATP-binding pocket, or the braces, and impair chromatin remodeling in vitro or diminish DNA accessibility in vivo, and therefore are loss-of-function missense mutations (Bultman et al., 2005; Dykhuizen et al., 2013; Hodges et al., 2018). This evidence concerns the gene SMARCA4 and cancer.