In contrast, our eleven cancer-associated mutations do not map to the RecA-like lobes themselves; they exclusively map to the structural hub, and involve the transition between the HSA and post-HSA domains (K382I and N384D), the post-HSA domain (K397Δ, R400C and S416M), the α2 helix (H452Y), the SuppH helix (R684W, R685H, and H687Y) and the braces (G943S and Q954W) (Figure 1C, color-coded by domain). Here, RAD51 is linked to cancer.