Therefore, the ability of polydatin and pioglitazone to inhibit ZEB1 nuclear translocation and increase miR‐203 expression is the key to attenuate the EMT in the protection against liver fibrosis associated with high fructose intake through the blockade of survivin‐mediated TGF‐β1/Smad signalling activation. The gene discussed is BIRC5; the disease is Hepatic fibrosis.