According to the HaploReg,35 RegulomeDB,36 and PROMO37 online databases, it is suggested that the CYP2R1 rs12794714 variant may influence the binding affinity of several transcription factors, including ELF1, HNF4, SMARCA4, CDX2, and PEA3 in different cell types such as the Caco‐2 colon cancer cell line. This evidence concerns the gene CYP2R1 and malignant colon neoplasm.