The AUC of ADAMTS13 and syndecan-1 was 0.91 (p < 0.0001) while ACE2, d-Dimer, PBR, and VEGF-A showed AUCs ≥ 0.85 (p < 0.0001) in predicting development of moderate-to-severe ARDS during hospital stay. Here, SDC1 is linked to acute respiratory distress syndrome.