For example, there is evidence that rs100637 (a SCZ-associated SNP, located in intron 3 of the CACNA1C gene) is associated with major depressive disorder (MDD), SCZ and attention deficit hyperactivity disorder, leads to changes in CACNA1C expression in both human carriers [5, 6] and induced human neurons [7]. The gene discussed is CACNA1C; the disease is major depressive disorder.