Kedra et al. [56] revealed that homozygous tsc2-deficient larvae (model of tuberous sclerosis complex, in which 90% of patients display seizures) exhibited the same behavioural response as described here for cacna1dasa17298/WT mutants i.e. a pronounced increase in locomotor activity of tsc2−/− larvae compared with their control counterparts in the dark phase of the light-dark stimulus task. The gene discussed is TSC2; the disease is tuberous sclerosis.