Previous study showed that let-7g-5p was significantly downregulated in GBM patients, and overexpressing let-7g-5p inhibited epithelial–mesenchymal transition (EMT) phenotypes and stem cell phenotypes and TMZ resistance by targeting V-set and immunoglobulin domain containing 4 (VSIG4) [23]. Here, VSIG4 is linked to glioblastoma.