We found that after silencing PRR11 by Liposome transfection, E-cad expression was up-regulated and Snail and N-cad expressions were down-regulated in breast cancer cells, and siPRR11 transfection with microbubble and ultrasound further enhanced the effects, suggesting that siPRR11 transfection with microbubble and ultrasound suppressed breast cancer cell metastasis in vitro. The gene discussed is CDH1; the disease is breast cancer.