Moreover, Cyclooxygenase-2 (COX-2), is one of the host genes that is highly induced upon KSHV de novo infection of human microvascular endothelial cells (HMVEC-d) and human foreskin fibroblast (HFF) cells [31–35], and COX-2 silencing or chemical inhibition significantly reduces the proliferation and invasiveness of KSHV-infected endothelial cells [31, 32,34–38]. This evidence concerns the gene PTGS2 and infection.