The Sprague-Dawley (SD) rat model in which PAH is induced by a combination of subcutaneous injection of a vascular endothelial growth factor inhibitor, Sugen 5416, and exposure to hypoxia (SuHx) can reproduce PAH-specific complex occlusive vascular remodeling such as plexiform lesions [9,10]. The gene discussed is VEGFA; the disease is pulmonary arterial hypertension.