MARK2 and colorectal carcinoma: For example, ITGB4 has been implicated in CRC progression and as a miR-21 target which represses ITGB4 leading to increased CRC cell migration [34]; STAT5A has been shown to promote E-cadherin and negatively regulate cell migration and invasion [35]; and MARK2 has been linked to regulation of epithelial polarity [36].