Top genes identified included both known CMM genes (ATM, CDKN2B, TYR, and CDKAL1) and genes that were previously unknown in CMM susceptibility, such as PRKDC, MLLT4, PLCE1, MAP2K2, IL1RN, and ATR. As a proof of principle analysis for the utility of DADA in gene prioritization, we applied the same ranking strategy in two additional CMM families with mutations in known CMM genes (POT1 and CDKN2A). The gene discussed is PLCE1; the disease is familial congenital mirror movements.