Based on the promising clinical immunogenicity of our five-peptide FRα vaccine, as well as the encouraging preclinical studies on Th17-inducing DC stimulation of ovarian tumor antigen-specific CD4+ T cell responses, we conducted a pilot clinical trial testing a vaccine composed of monocyte-derived autologous Th17-inducing DCs pulsed with FRα epitopes. The gene discussed is CD4; the disease is ovarian neoplasm.