In brief, treatment of monocyte-derived DCs with a p38 inhibitor in combination with IL-15 diminished PD-L1 expression and indoleamine 2,3-dioxygenase function, and favored stimulation of ovarian tumor antigen-specific Th1/Th17 CD4+ T cell responses, while also reducing CD4+Foxp3+ Treg expansion37. Here, CD4 is linked to ovarian neoplasm.