PRM2 and male infertility: Therefore, in the present meta-analysis including a meta-regression analysis of 17 studies, we investigated 13 PRM polymorphisms and then focused on the association between four functional PRM1 (rs737008 and rs2301365) and PRM2 (rs1646022 and PRM2 rs2070923) polymorphisms and male infertility susceptibility in case–control studies.