About PRM2 rs2070923 polymorphism, the G allele had an elevated risk in male infertility compared to male fertility (OR 1.38; 95% CI 1.18, 1.63; P < 0.0001), which was similar to the G allele (OR 1.26; 95% CI 1.09, 1.46; P = 0.001) and GG genotype (OR 1.43; 95% CI 1.06, 1.94; P = 0.02) in the studies with hospital-based controls. The gene discussed is PRM2; the disease is male infertility.