Future in vivo MM studies using an inducible Cre:flox mouse model that causes osteocyte knockout (Dmp1-Cre) of Vegf-a or Fgf23 are needed to determine the relative contributions of this cell type to the elevated marrow angiogenesis observed in MMBD21,27,32,56–58. The gene discussed is FGF23; the disease is Miyoshi myopathy.