Further, elevated levels of marrow angiogenesis correlate with decreased MM patient survival, suggesting that development of MMBD and changes in vascularity in the bone microenvironment are linked3 While it is unknown whether osteocytes contribute to the observed increases in marrow vascular density in MM patients, it has been reported that hypoxia can increase levels of osteocyte-specific proteins Dmp1 and Mepe ex vivo20. The gene discussed is MEPE; the disease is Miyoshi myopathy.