CMIP and chronic obstructive pulmonary disease: The variant rs74469188 identified in COPD-enriched African Americans from TOPMed also showed statistically significant association with FVC in UK Biobank European ancestry samples (chr16: 81,611,365, CMIP intronic; UK Biobank BOLT-LMM P = 1.4 × 10−5), but the direction of effect was not consistent with that observed in TOPMed (Table 3).