In conditional analysis accounting for variants within known loci (Supplementary Data 2), we also found a secondary variant, rs9920270, around the CHRNA3/5 region variant rs12914385 associated with severe COPD in COPD-enriched analysis (conditional beta = 0.28 and P = 2.25 × 10−7 for conditional association test; Supplementary Data 11). The gene discussed is CHRNA3; the disease is chronic obstructive pulmonary disease.