The variant rs371740347 intronic to CFHR5 was associated with “respiratory failure, insufficiency, arrest” (UK Biobank MAF = 0.01; MAC in cases vs. controls = 81 vs. 6,319; P = 6.9 × 10−5), though the allele increasing FVC was associated with increased risk of this phenotype (Table 3). Here, CFHR5 is linked to respiratory failure.