FTO and connective tissue disorder: Phenome-wide analyses examining the novel variants from the TOPMed WGS analyses (Supplementary Data 2) for associations in the UK Biobank showed the variant rs7188378 intronic to FTO was associated with unspecified diffuse connective tissue disease (Table 2, Supplementary Data 19; UK Biobank MAF = 0.50; MAC in cases vs. controls = 3003 vs. 399,121; P = 7.1 × 10−14 for SAIGE score test) and diffuse diseases of connective tissue (MAC in cases vs. controls = 3771 vs. 399,096, P = 6.4 × 10−13 for SAIGE score test).