Notably, the largest-to-date genome-wide association study (GWAS) for PTSD recently found genome-wide level associations between variants of CRHR1, the gene encoding corticotropin-releasing hormone (CRH) receptor-type 1, genetically regulated brain-specific CRHR1 expression, and PTSD diagnosis and symptom clusters11,12, along with its identification in large GWAS of anxiety and habitual alcohol use13,14. This evidence concerns the gene CRH and post-traumatic stress disorder.