Reduced expression of PDGFB (Fig. 6c) was also observed in LTB-treated RASSF1A-depleted CNE-1 cells, indicating that actin cytoskeletal rearrangement acts upstream of YAP1 nuclear import and subsequent activation in RASSF1A-modulated NPC cells. This evidence concerns the gene YAP1 and nasopharyngeal carcinoma.