SCML1 and Miyoshi myopathy: Noncoding regulatory regions additionally disrupted at relapse, included those targeting XBP1, RBX1, and SCML1. Common pathways affected by coding and noncoding mutations arising in MM relapse included those associated with WNT-signalling, MAPK-signalling, and NOTCH-signalling, base excision repair, cell cycle, telomere maintenance, and cellular senescence (Table 2).