In addition to known coding drivers, we extend the number of potential non-coding drivers in MM, including those associated with CXCR4 and BIRC3. Somatic mutations in BCL6 promoters are common in MM52; however, since the gene is a common target of normal activation-induced deaminase (AID) in the germinal centre53, the relevance of these promoter mutations to MM biology is questionable. This evidence concerns the gene BCL6 and Miyoshi myopathy.