Over half of MM tumours have chromosomal translocations involving the immunoglobulin heavy chain locus, which leads to overexpression of oncogenes (CCND1, CCND3, MAF, MAFB, WHSC1/MMSET, and FGFR3) as an initiating event1. The gene discussed is FGFR3; the disease is Miyoshi myopathy.