Although body weight, mean BP, kidney weight, serum Ang-II, and creatinine were not different between Ace2−/y and WT controls, kidney Ang-II levels showed a threefold increase at baseline, and induction of type 1 diabetes led to an earlier onset of albuminuria and a more severe glomerular/tubulo-interstitial damage in Ace2−/y mice62. This evidence concerns the gene AGT and type 1 diabetes mellitus.