Importantly, in all the tested TMAs we found that high expression of pAKT positively correlated with expression of TROLL-2 and TROLL-3 and cytoplasmic expression of WDR26 (Fig. 5a and Supplementary Fig. 6e′-b′′), thus indicating that this novel interplay that we have identified is relevant in multiple tumour types. This evidence concerns the gene WDR26 and neoplasm.