On the contrary, WDR26-ΔNES showed no appreciable difference in migration or invasion compared to cells treated with empty vector (Fig. 6d and Supplementary Fig. 6f–k), indicating that cytoplasmic WDR26, but not nuclear WDR26, functions downstream of TROLL-2 and TROLL-3 and plays a crucial role in cancer progression. This evidence concerns the gene WDR26 and cancer.