AKT1 and cancer: Given the high frequency of oncogenic activating mutations affecting the PI3K/AKT pathway in human tumours60, our data provide preclinical rationale suggesting that the inactivation of TROLL-2 and TROLL-3, the nuclear sequestration of WDR26, or interfering with the interaction between the TROLLs, WDR26 and AKT might be effective in halting cancer progression and resistance to AKT targeted therapy.