Interestingly, SHANK2 disruption and t(11;17) were frequently accompanied by 11q13.3 copy number gains associated with the chromosome 11 breakpoint, where six genes at this locus showed increased expression in 11q13.3-gained samples, including CCND1, a cancer gene with well-established oncogenic activity in neuroblastoma29 (Supplementary Fig. 8a, bottom, P = 0.003 by two-sided Wilcoxon rank-sum test). The gene discussed is CCND1; the disease is cancer.