However, no differences in the frequency of CD45.2+ Th17 (CD4+IL-17A+FoxP3–) cells were observed between the 2 groups of mice (Figure 4G and Supplemental Figure 8C), pointing to increased arthritis in recipients of cTregs being dependent on enhanced instability rather than reduced suppressive ability of cTregs. This evidence concerns the gene CD4 and arthritic joint disease.