FOXP3 and arthritic joint disease: However, no differences in the frequency of CD45.2+ Th17 (CD4+IL-17A+FoxP3–) cells were observed between the 2 groups of mice (Figure 4G and Supplemental Figure 8C), pointing to increased arthritis in recipients of cTregs being dependent on enhanced instability rather than reduced suppressive ability of cTregs.