We then evaluated the impact of ErsA on the inflammatory response of the IB3-1 cells by monitoring the infection-induced secretion of the proinflammatory marker interleukin 8 (IL-8), the major chemokine associated with neutrophil extravasation from the vasculature into the lumen of the airways when respiratory epithelial cells are exposed to P. aeruginosa. The gene discussed is CXCL8; the disease is infection.