GATA6 and coronary artery disorder: Among >4000 CHD patients enrolled and studied by WES through National Heart, Lung, and Blood Institute’s Pediatric Cardiac Genomics Consortium (PCGC) (Homsy et al., 2015; Jin et al., 2017), we identified nine heterozygous de novo variants: four LoF (LoF) and five damaging missense variants in GATA6 (Figure 1A).