GATA6 and congenital diaphragmatic hernia: While often informative, prior studies of mice with one inactivated Gata6 allele have either subtle dysmorphic aortic valves (Gharibeh et al., 2018) or no CHD (Lepore et al., 2006) and notably lack pancreatic agenesis or congenital diaphragmatic hernia that occur in human CHD patients with damaging GATA6 variants (Chao et al., 2015; De Franco et al., 2013; Shi et al., 2017).