Among PCGC CHD patients and 61 previously reported CHD patients with pathogenic GATA6 variants (Figure 1B) there were a preponderance of outflow tract malformations, including persistent truncus arteriosus, double-outlet right ventricle, tetralogy of Fallot, as well as aortic and pulmonary valve and septation defects (Kelly, 2012). This evidence concerns the gene GATA6 and Tetralogy of Fallot.