The diagnostic ability of MLKL mRNA achieved very high diagnostic accuracy 0.9277 (95% CI 0.878–0.978) with high sensitivity (81.36%) and specificity (93.3%), implying that MLKL mRNA of PBMCs may be a potential diagnosis biomarker for SLE (Fig. 4). The gene discussed is MLKL; the disease is systemic lupus erythematosus.