Some examples of DHPG-responsive mRNAs and RPFs that are high confidence SFARI autism genes (https://gene.sfari.org, score 1 or 2) are shown in Fig. 4c for Shank3, Dlg4, and Ache. Dlg4 mRNA encodes PSD-95, which has increased mRNA and protein levels following DHPG-mGluR signaling [55]. This evidence concerns the gene SHANK3 and autism.