Programmed death-ligand-1 (PD-L1), an immune inhibitory protein, binds to programmed death-1 (PD-1) expressed on the tumor-infiltrating lymphocytes (TILs), such as T-cells, B-cells, dendritic cells, and natural killer T-cells to suppress anti-cancer immunity and enable neoplastic growth [7]. This evidence concerns the gene CD274 and neoplasm.