NANOG and neuroblastoma: Indeed, the mouse zinc finger transcription factor Zfp281 (or the human homologue ZNF281), involved in the control of neuronal progenitor stemness by inhibiting Nanog expression in mice through recruitment of the inhibitory complex NuRD on the Nanog promoter, is significantly expressed in neuronal cells, and significantly repressed during neuronal differentiation, including neuroblastoma [57].