General laboratory parameters, including complete blood count, urinalysis results, liver and renal function indicators, erythrocyte sedimentation rate (ESR), blood eosinophil count and high-sensitivity C-reactive protein (hs-CRP), were determined in the RDD mimic IgG4-RD and IgG4-RD groups, and no significant differences were found between them. The gene discussed is CRP; the disease is sinus histiocytosis with massive lymphadenopathy.