WRN and cancer: Our previous work suggested that the metabolic changes induced by WRN depletion in cancer cells are caused by a posttranscriptional mechanism of deregulation [25], and we confirmed by RT-qPCR that mRNA levels of the metabolic enzymes G6PD and IDH1 are not downregulated after shWRN induction in HeLa cancer cells (Supplementary Fig. 1A).