The α-Synuclein levels were also elevated in the cerebrum of Smox/Sat1-dKO at 8 (mild ataxia) and 14+ (severe ataxia) weeks of age (Supplemental Fig. 6), but their expression levels were lower in comparison to those found in the cerebellum of the same animals (Fig. 8a). The gene discussed is SAT1; the disease is Ataxia.