TGM2 has maladaptive roles in neurodegenerative diseases such as Parkinson’s disease, multiple sclerosis (MS), amyotrophic lateral sclerosis, and Huntington’s disease [40–42, 62, 63], and mediates the polyamination of proteins associated with neurodegenerative diseases (e.g., Tauopathies and Huntington's disease) [32, 64, 65]. This evidence concerns the gene TGM2 and Huntington disease.