Therefore, we hypothesis that the elevated expression of the four angiogenic factors in HUVECs might due to the enhanced transcription mediated directly by more YB-1 transferred via exosomes, or indirectly by more other angiogenic upstream factors with their mRNA stabilized by YB-1 and the supposed mechanism of YB-1 promoting angiogenesis in GC was shown in Fig. 6. This evidence concerns the gene YBX1 and gastric cancer.