However, whether the DNA methylation of KLF7 in the adipose tissue had associations with its expression and the blood metabolic indicators, including the levels of glucose (Glu), phospholipids (PL), total cholesterol (TC), triglyceride (TG), low-density lipoprotein (LDL) and high-density lipoprotein (HDL), which were correlated with the T2DM and obesity, is still unclear. This evidence concerns the gene KLF7 and obesity disorder.