DACT3 and inflammatory bowel disease: As there is increasing interest in exploring new alternatives for IBD treatment, this research suggests at least three potential opportunities: i) use of F. prausnitzii itself, ii) use of drugs to modulate Dact3 expression (such as histone deacetylases) and iii) heterologous delivery of Dact3 (either as a cDNA or a protein) using food-grade live vectors.39,40 For these, further studies on Dact3-knockout mice will be necessary to understand the physiological functions of Dact3.