REN and hypertensive disorder: The timing of effect of fibroblast Nox2 on ANG II–induced hypertension contrasts to the effects of endothelial Nox2 studied in the same model, which occur earlier and are related to altered vascular tone.16 Our results add to the emerging concept of Nox2 as a master regulator of ANG II–induced hypertension and also suggest that GDF6 could be a potential target to inhibit vascular remodeling during increased activation of the renin-angiotensin system.