It was found that myeloid cell Nox2 modulates basal BP through changes in vascular tone but has minimal effects on ANG II–induced hypertension.16 However, endothelial cell Nox2 did not affect basal BP but contributed to the early phases (the first 5 days) of ANG II–induced hypertension via ROS-induced changes in vessel tone.16 In the current study, it was notable that the effects of fibroblast Nox2 on ANGI II–induced hypertension were most evident towards the end of infusion (after at least 1 week), consistent with a mechanism that involves gradual thickening of the vascular media. This evidence concerns the gene AGT and hypertensive disorder.