ADA and cardiovascular disorder: Suoza Vdo et al. revealed increased activities of eNPP and e5′NT and decreased eADA activity in platelets of patients with Chagas disease contributed to decreased platelet aggregation, suggesting that the purinergic system is significantly involved in the thromboregulation [132], whereas, Leal et al. demonstrated that serum ADA activity positively correlated with increased platelet aggregation in pregnant women with an increased risk of cardiovascular disease [133].