In contrast, in other cardiac-restricted TNF-α overexpressing models (TNF1.6 and MHCsTNF strains), most of the transgenic mice survived and developed mild inflammation and dilated cardiomyopathy phenotype with cardiac tissue remodeling as well as systolic and diastolic dysfunction associated with atrial and ventricular arrhythmias [81,82,83]. The gene discussed is TNF; the disease is dilated cardiomyopathy.