In mouse models of melanoma, pharmacologic inhibition of the serine/threonine kinase Akt achieved by using Akt inhibitor VIII (PubChem Compound Identification: 10196499) during in vitro expansion of TIL has led to the generation of a long-lived and memory-like T cell pool with potent anti-tumor activity [76]. This evidence concerns the gene AKT1 and neoplasm.