TMPRSS2 and COVID-19: In patients with COPD and asthma, although there is still very little scientific evidence, the treatment with inhaled glucocorticoids (IGC) could have a “protective effect” against COVID-19 since they may decrease the expression of the ACE2 receptor genes and the TMPRSS2 transmembrane protease genes, both key for the virus to enter cells and make copies of itself [25].