Abdominal obesity was significantly associated with rectal cancer among noncarriers of SUCLG2-rs35494829 (1.35 [1.12–1.63]), OGDHL-rs11101224 (1.37 [1.12–1.68]), and OGDHL-rs751595 (1.40 [1.14–1.72]). The gene discussed is SUCLG2; the disease is Abdominal obesity.