Rs35494829 C > T in the SUCLG2 gene exhibited a significant association with colorectal cancer (OR [95% CIs]; CT, 0.89 [0.80–0.98] compared to CC; CT + TT, 0.88 [0.80–0.97] compared to CC; per T allele, 0.88 [0.81–0.96]) and colon cancer (CT, 0.83 [0.73–0.94] compared to CC; CT + TT, 0.82 [0.72–0.92] compared to CC; per T allele, 0.88 [0.81–0.96]). This evidence concerns the gene SUCLG2 and colonic neoplasm.