Interestingly, early disseminating cases were significantly enriched for five altered (via mutation or copy-number deletion) tumour suppressor driver genes, including BRCA2 (MIM: 600185; early: 100%, 4/4 cases vs. late: 26.9%, 7/26 cases), FOXO1 (MIM: 136533; early: 100%, 4/4 cases vs. late: 30.8%, 7/26 cases), GPC5 (MIM: 602446; early: 100%, 4/4 cases vs. late: 23%, 6/26 cases), RB1 (MIM: 614041; early: 100%, 4/4 cases vs. late: 23%, 6/26 cases), and SOX21 (MIM: 604974; early: 100%, 4/4 cases vs. late: 27%, 7/26 cases) (BH adjusted p < 0.01; Chi-squared test). The gene discussed is RB1; the disease is neoplasm.