A clonal driver mutation in MYCN (MIM: 164840; CRC-190), and subclonal driver mutations in ELF4 (MIM: 300775; 083-03), PTPRB (MIM: 176882; CRC-233 lymph node metastasis), FUS (MIM: 137070), and ERCC4 (MIM: 133520) in CRC-449 were all specific to metastatic tumours. The gene discussed is ERCC4; the disease is colorectal carcinoma.