SMAD2 and cancer: Recurrent driver mutations in the cohort were found encompassing cancer genes with known roles in CRC [24,25], such as APC (MIM: 611731; 53.3%, 16/30 cases), TP53 (MIM: 191170; 53.3%, 16/30 cases), KRAS (MIM: 190070; 46.7%, 14/30 cases), SMAD4 (MIM: 600993; 20%, 6/30 cases), PIK3CA (MIM: 171834; 10%, 3/30 cases), and SMAD2 (MIM: 601366; 6.7%, 2/30 cases), consistent with previous reports [26,27,28,29].