RAC1 and colorectal carcinoma: Similarly, several driver copy number amplifications encompassing oncogenes were found specific to metastatic lesions, including MUC16 (MIM: 606154; CRC-449), PIK3CA and TBL1XR1 (MIM: 608628; 197-064), MAML2 (MIM: 607537) and PRKACA (MIM: 601639; 083-03), CARD11 (MIM: 607210), ETV1 (MIM: 600541), HNRNPA2B1 (MIM: 600124), HOXA11 (MIM: 142958), HOXA13 (MIM: 142959), HOXA9 (MIM: 142956), MACC1 (MIM: 612646), and RAC1 (MIM: 602048), all found exclusively in patient 306-090 (Table S4 and Figure S1).