The present study characterized geraniol as a cardioprotective agent in MI, which is possibly associated with the modulation of the Keap1/Nrf2 pathway, enhancing the nuclear accumulation of Nrf2 and the upregulation of phase II antioxidant enzyme expression such as HO-1, SOD, CAT, GPx, and GST. Here, NFE2L2 is linked to myocardial infarction.