Altered cancer genes represented by these mouse models include the human equivalent genes TP53, BRCA2, HLA-A, PTPRB/C/K, KRAS, ROBO2, FGFR1, CTCF, JAK1/3, ERBB4, KMT2A, and KMT2D, which have been biologically studied in human HNC, although their effects on immune-relevant contexts have not been investigated. Here, KMT2D is linked to cancer.