Common gene copy losses represented by both models with HNC patient relevance are Robo2, an important candidate tumor suppressor of the ROBO–SLIT pathway (16qC3), and Fancb gene (XqF5, human FANCB) involved in the Fanconi anemia (FA) pathway, which is altered in subsets of HNC patients. Here, ROBO2 is linked to neoplasm.