PIK3CA and glioblastoma: GBM with wildtype IDH1 have a worse prognosis than IDH1-mutant GBM [56], and it has been recently reported that IDH1 overexpression, and the subsequent increase in α-ketoglutarate (α-KG), is associated with increased migration of GBM cells and enhanced PI3K/AKT/mTOR pathway activity [55].