FKB treatment (0–10 μg/mL, 24 h) dose-dependently favored the expression of activator Bax with a dramatic decrease in the expression of inhibitor Bcl-2 in A375 and A2058 cells (Figure 2C,D) and signified the FKB-mediated apoptosis activation in melanoma cells. The gene discussed is BAX; the disease is melanoma.