Primary outcomes that were subjected to meta-analysis included: aortic clamping time, arrythmia, cardio-pulmonary bypass (CPB) duration, ICU length of stay, blood loss, duration of mechanical ventilation, duration of surgery, exogenous insulin treatment in the ICU postoperatively, arrythmia, acute myocardial infarction (AMI), acute atrial fibrillation (AAF), any infectious complications, inotropic drugs usage, postoperative nausea and vomiting (PONV), transfusion requirement and vasoactive drugs usage. This evidence concerns the gene INS and myocardial infarction.