The synergism from combination of OA and ART with CS, however, is not surprising given the fact that OA and ART are known as apoptotic inducers (through increasing Bax, decreasing Bcl-2, and up-regulating of caspases), as well as they exhibit tumour inhibition effect (through the down-regulation of NF-κB and other signalling pathways) and anti-angiogenic effect (through the decreasing of VEGF) [10,17]. Here, BAX is linked to neoplasm.