PSA3 (also known as PSMA3) [15], was down-regulated in cis-resistant cell line as compared to its sensitive counterpart when A2780 was used as a reference, this is consistent with finding of Moghanibashi et al. in which PSA3 was reported to be down-regulated in ESCC [135]. Here, PSMA3 is linked to esophageal squamous cell carcinoma.