Expression of APG2 was lowered below threshold of detection after treatment with synergistic combinations of (CS and ART using 4/0 h), (CS and OA using 0/4), (CS and ART using 0/0 h) and (CS and OA using 0/0), that might have inhibited its behaviour as heat shock protein exposing cells to the toxic effect of CS, thereby increased cell apoptosis, indicating a causal relationship between APG2 expression and platinum resistance in ovarian cancer. Here, HSPA4 is linked to ovarian cancer.