S100A8 and gastric cancer: In Western countries, subjects infected with cagA-positive (cagA+) strains compared to those infected with cagA-negative (cagA−) strains of H.p. are at a 1.7–2.8-times higher risks of both PUD or gastric cancer [57,67,69], whereas, in the East Asian population, in which most H.p. strains carry cagA gene, these risks are 2.8–4.6-times higher [67].