In adolescents, HPI was not accompanied by significant changes in serum levels of bone formation markers (N-terminal cross-links of human procollagen type I (P1NP), N-mid-osteocalcin (OC) and bone-specific alkaline phosphatase (bALP)), bone resorption marker (β-collagen I carboxy terminal telopeptide (β-CTX)), calcium and phosphate, as well as in circulating estradiol, intact parathyroid hormone (PTH) and ferritin levels, but a tendency to increased bone resorption (as reflected by higher β-CTX levels, p = 0.063) was observed [105]. Here, BGLAP is linked to hyperprolinemia type 1.