S100A8 and anemia: Notable, certain H.p. strain-specific virulence constituents, in particular cagA, are significantly associated not only with an increased risk of gastroduodenal diseases but also with a number of extra-intestinal disorders and diseases associated with OP/OF, including iron deficient anemia, ITP, acute coronary syndromes, serum dyslipidemia, Parkinson’s disease, MAFLD, metabolic syndrome, DM, thyroiditis, liver cirrhosis and glaucoma.