In contrast, a Norwegian study [135] found that, in patients with chronic atrophic gastritis, compared to sex- and age-matched controls, bone formation markers (OC, sclerostin, OPG and OPG/RANKL ratio) were lower and the incidence of OP was higher (the latter abnormality only in males). This evidence concerns the gene TNFRSF11B and chronic atrophic gastritis.