One of the first pieces of evidence suggesting Nrf2 involvement in HCC emerged from reports in which the activity of D-T diaphorase (now known as Nqo1) and G6PD, both now well-known Nrf2 target genes, was increased in rat chemically-induced preneoplastic foci/nodules [103,104,105]. This evidence concerns the gene NQO1 and hepatocellular carcinoma.