Overall, although the regulation of Nrf2 by miRNAs is a promising area of research, due to the very little information about the interaction between miRs and Nrf2 in HCC, the role of small non-coding RNAs in modulating the Keap1/Nrf2 pathway in liver tumors remains largely elusive. This evidence concerns the gene KEAP1 and hepatocellular carcinoma.