The eIF4A1‐facilitated translation of oncogenic mRNA repertoire leads to the synthesis of many oncoproteins, such as survivin or BIRC5, myeloid cell leukemia 1(MCL1), cyclin D1, cyclin D3, mucin‐1C (MUC‐1C), Rho kinase 1 (ROCK1), ADP ribosylation factor 6 (ARF6), and murine double minute 2/human double minute 2 (MDM2/HDM2) and ADP ribosylation factor 6 (AFR6), which are vital for tumor cell survival both at primary and metastatic sites, proliferation, migration, local invasion, metastasis, and chemoresistance.11, 12, 13, 14, 15, 16. This evidence concerns the gene MDM2 and neoplasm.